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Positive estrogen receptors in breast cancer

Key Points: Estrogen and progesterone receptors are found in breast cancer cells that depend on estrogen and related hormones to grow. All patients with invasive breast cancer or a breast cancer recurrence should have their tumors tested for estrogen and progesterone receptors. This testing should be performed by an accredited laboratory that follows specific testing procedures and handles the samples in a consistent way.
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Progesterone & Breast Cancer

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Hormone Therapy for Breast Cancer Fact Sheet - National Cancer Institute

Research Table Topics Table Estrogen receptor status and overall survival This summary table contains detailed information about research studies. Summary tables are a useful way to look at the science behind many breast cancer guidelines and recommendations. Learn how to read a research table. Estrogen receptor status helps guide breast cancer treatment. Estrogen receptor-positive ER-positive tumors express have a lot of estrogen receptors. Estrogen receptor-negative ER-negative tumors do not express have few or no estrogen receptors.
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Staging & Grade

Hormone receptor tests are both prognostic and predictive. Hormone receptors also provide information about treatment options. For early stage cancer, these treatments include tamoxifen and a class of drugs called aromatase inhibitors or AIs.
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Breast cancer cells taken out during a biopsy or surgery will be tested to see if they have certain proteins that are estrogen or progesterone receptors. When the hormones estrogen and progesterone attach to these receptors, they fuel the cancer growth. Cancers are called hormone receptor-positive or hormone receptor-negative based on whether or not they have these receptors proteins. Knowing the hormone receptor status is important in deciding treatment options.
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