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Structure[ edit ] Perlecan consists of a core protein of molecular weight kDa to which three long chains each approximately kDa of glycosaminoglycans often heparan sulfate , HS, but can be chondroitin sulfate , CS are attached. The core protein consists of five distinct structural domains. Although HS chains are not required for correct folding and secretion of the protein, lack of HS or decreased sulfation can decrease perlecan's ability to interact with matrix proteins. Removal of HS chains may affect matrix organization and endothelial barrier function. Domain IV consists of a series of IG modules.
George Washington acquired acres in what is now West Virginia because it contained an oil and gas spring. This was in , making the father of our country the first petroleum industry speculator. Today, it stands as a tribute to Srila Prabhupada and is visited by thousands of people yearly. The palace features breathtaking stained glass windows and beautiful grounds. West Virginia Penitentiary West Virginia Penitentiary is a historical site that is over years old.